Also contrast Easy Sex Change; though it has at least a of realism, it minimizes or ignores many physical, psychological, and/or social complications of sex change.
Also see Trans Equals Gay for common misconceptions.
There's a general craving by most of the trans community for more representation of them as just regular people — just like not every female character's story has to be about battling sexism or traditional gender roles, many trans people too would like to see themselves depicted in all traditional narratives.
Despite the trope name, it is very important to note that the currently preferred term in English is transgender, not transsexual.
In many non-Western and ancient or medieval societies, transgender people are seen as a different gender in itself, and there is a separate category for them, one that is different from the binary 'men' and 'women'.
They are often described collectively as 'third genders.' These societies traditionally have separate social spaces for third gender people, which are separate from both men's social spaces and women's social spaces.
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As a matter of fact, there is still a lot that isn't understood, and because research on the subject is always yielding new discoveries in relatively quick succession, in addition to shifting societal norms and growing understanding that even biology isn't as cut-and-dry as it once was thought to be.
Ambiguous Gender Identity is a trope for characters who may or may not be transgender.
Has nothing to do with Transhumans; the shared root "trans-" Patty: Hello, my name's Patty.
The language around trans discourse changes very rapidly, due to being de-pathologised and re-written by trans people themselves instead of by outside onlookers.
The demarcation between gender, sex, gender expression and orientation is also subject to constant historical and cultural shifts in perspective — the realisation that these are different things with only some overlapping points is slowly seeping into our modern narratives.